Life Extension No Flush Niacin

Name: Life Extension No Flush Niacin
Brand: Life Extension
SKU: 737870373100
Price: 18.59 GBP
Availability: InStock

Brands: Life Extension

£18.59

Life Extension's take on vitamin B3, in a caps format that is easy to keep to day after day.

Why people take it

Vitamin B3 contributes to normal energy-yielding metabolism
Vitamin B3 contributes to the maintenance of normal skin and mucous membranes
Vitamin B3 contributes to the reduction of tiredness and fatigue

How to use

Take as directed on the pack, ideally with food and at the same time each day.

Good to know

Format: caps
Caffeine free

A food supplement, not a substitute for a varied diet and healthy lifestyle. Do not exceed the stated dose. Keep out of reach of children.

Quantity

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Categories : Caffeine-Free Supplements, Everyday Health Supplements, Life Extension, Vitamin B12 & B Complex, Vitamins & Supplements

SKU: 737870373100

At a glance

£0.18

per daily dose

Limited

evidence for niacin (nicotinic acid)

Our honest take

"No flush" niacin is inositol hexanicotinate: each capsule gives 800 mg of the compound, labelled as 640 mg niacin equivalents, about 40 times the daily reference intake. The compound releases only small amounts of free niacin, which is why it does not cause skin flushing, but that also means its effects are uncertain and it has not been shown to do what high-dose niacin was once prescribed for. If you simply want vitamin B3, a multivitamin covers it for pennies.

You have a specific reason to take inositol hexanicotinate and have discussed it with your doctor
You want to manage cholesterol or heart health: speak to your GP about proven treatments
You have liver disease, diabetes or gout, or take statins or blood-thinning medicines
You are pregnant or breastfeeding

The science

Niacin (nicotinic acid)· evidence: Limited

Niacin (vitamin B3) helps the body release energy from food. Adults need about 13 to 17 mg a day and most people get plenty from meat, fish, wholegrains, nuts and fortified foods, so deficiency is rare in the UK.

High-dose nicotinic acid (hundreds of milligrams to grams a day) used to be prescribed to change blood fats. Large trials found it did not reduce heart attacks or strokes in people already on statins, and it caused more side effects, so it is no longer used this way in the UK. Self-dosing at these levels is not advised.

Nicotinic acid causes "niacin flush": warmth, redness and itching of the skin, usually within 30 minutes. Sustained-release versions flush less but have been linked to more liver problems at high doses. Inositol hexanicotinate ("no flush niacin") releases little free niacin and its effects are uncertain.

Authorised health claim
Niacin contributes to normal energy-yielding metabolism. Niacin contributes to normal functioning of the nervous system. Niacin contributes to normal psychological function. Niacin contributes to the maintenance of normal mucous membranes. Niacin contributes to the maintenance of normal skin. Niacin contributes to the reduction of tiredness and fatigue. (Applies where a daily dose gives at least 15% of the NRV, i.e. 2.4 mg.)

Typical dose: Adults need about 13 mg (women) to 17 mg (men) a day (NRV on labels: 16 mg).

Safety: The UK Expert Group on Vitamins and Minerals set a guidance level of 17 mg a day of nicotinic acid from supplements, mainly to avoid flushing; EFSA's upper level is 10 mg a day. Doses of 500 mg or more, especially sustained-release forms, can cause liver damage, raised blood sugar, gout flares and stomach upset. Do not take high-dose niacin if you have liver disease, diabetes, gout or a stomach ulcer, or with statins, unless a doctor supervises it.

Research we looked at:
Expert Group on Vitamins and Minerals (2003). Safe Upper Levels for Vitamins and Minerals. Food Standards Agency.
HPS2-THRIVE Collaborative Group. Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med 2014;371:203–212.
EFSA Scientific Committee on Food (2002). Opinion on the tolerable upper intake levels of nicotinic acid and nicotinamide (niacin).
NHS. Vitamins and minerals: niacin (vitamin B3). nhs.uk/conditions/vitamins-and-minerals/vitamin-b

Ingredients & nutrition

Per daily dose (1 capsule): inositol hexanicotinate 800 mg, providing niacin 640 mg NE (4,000% NRV) and inositol 160 mg. 100 capsules, 100 daily doses.

Other ingredients: gelatine (capsule), vegetable stearate. Not suitable for vegetarians.

Always check the pack you receive, as manufacturers sometimes update recipes.

How to use

Label directions: 1 capsule a day with food. Do not exceed the stated daily dose. Speak to your doctor first if you have liver problems, diabetes or gout, or take cholesterol medicines.

Price per dose & how it compares

Product	Size	Price	Per daily dose
This product	100 caps	£18.59	£0.18
Life Extension Vitamin B3 Niacin		from £8.25	£0.08
Osavi Niacinamide		from £6.95	£0.12
Doctor's Best Sustained-Release Niacin		from £20.60	£0.17

Cost per daily dose lets you compare packs of different sizes fairly.Worked out from our current prices.

Food supplements should not replace a varied, balanced diet and healthy lifestyle. General information, not medical advice. Speak to your GP or pharmacist first if you are pregnant or breastfeeding, have a medical condition or take medication.