Doctor's Best Sustained-Release Niacin

Name: Doctor's Best Sustained-Release Niacin
Brand: Doctor's Best
SKU: 753950002425
Price: 20.6 GBP
Availability: InStock

Brands: Doctor's Best

£20.60

Doctor's Best Sustained-Release Niacin keeps it simple: vitamin B3, in a tablets format, 120 tablets per pack.

Why people take it

Vitamin B3 contributes to normal energy-yielding metabolism
Vitamin B3 contributes to the maintenance of normal skin and mucous membranes
Vitamin B3 contributes to the reduction of tiredness and fatigue

How to use

Take as directed on the pack, ideally with food and at the same time each day.

Good to know

Format: tablets
Caffeine free

A food supplement, not a substitute for a varied diet and healthy lifestyle. Do not exceed the stated dose. Keep out of reach of children.

Quantity

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Categories : Caffeine-Free Supplements, Doctor's Best, Everyday Health Supplements, Vitamin B12 & B Complex, Vitamins & Supplements

SKU: 753950002425

At a glance

£0.17

per daily dose

Limited

evidence for niacin (nicotinic acid)

Our honest take

A sustained-release nicotinic acid (vitamin B3) tablet with 500 mg per tablet. That is about 30 times the UK guidance level of 17 mg of nicotinic acid a day from supplements, and the slow-release form, while causing less flushing, has been linked to liver damage at high doses. High-dose niacin is no longer used in the UK to manage blood fats because large trials showed no benefit on heart attacks or strokes. We would not recommend taking this without a doctor's supervision.

Your doctor has specifically advised sustained-release niacin and is monitoring your liver function
You want a general B3 or energy supplement: a multivitamin covers your needs safely
You have liver disease, diabetes, gout or a stomach ulcer, drink alcohol heavily, or take statins or blood-pressure medicines
You are pregnant or breastfeeding

The science

Niacin (nicotinic acid)· evidence: Limited

Niacin (vitamin B3) helps the body release energy from food. Adults need about 13 to 17 mg a day and most people get plenty from meat, fish, wholegrains, nuts and fortified foods, so deficiency is rare in the UK.

High-dose nicotinic acid (hundreds of milligrams to grams a day) used to be prescribed to change blood fats. Large trials found it did not reduce heart attacks or strokes in people already on statins, and it caused more side effects, so it is no longer used this way in the UK. Self-dosing at these levels is not advised.

Nicotinic acid causes "niacin flush": warmth, redness and itching of the skin, usually within 30 minutes. Sustained-release versions flush less but have been linked to more liver problems at high doses. Inositol hexanicotinate ("no flush niacin") releases little free niacin and its effects are uncertain.

Authorised health claim
Niacin contributes to normal energy-yielding metabolism. Niacin contributes to normal functioning of the nervous system. Niacin contributes to normal psychological function. Niacin contributes to the maintenance of normal mucous membranes. Niacin contributes to the maintenance of normal skin. Niacin contributes to the reduction of tiredness and fatigue. (Applies where a daily dose gives at least 15% of the NRV, i.e. 2.4 mg.)

Typical dose: Adults need about 13 mg (women) to 17 mg (men) a day (NRV on labels: 16 mg).

Safety: The UK Expert Group on Vitamins and Minerals set a guidance level of 17 mg a day of nicotinic acid from supplements, mainly to avoid flushing; EFSA's upper level is 10 mg a day. Doses of 500 mg or more, especially sustained-release forms, can cause liver damage, raised blood sugar, gout flares and stomach upset. Do not take high-dose niacin if you have liver disease, diabetes, gout or a stomach ulcer, or with statins, unless a doctor supervises it.

Research we looked at:
Expert Group on Vitamins and Minerals (2003). Safe Upper Levels for Vitamins and Minerals. Food Standards Agency.
HPS2-THRIVE Collaborative Group. Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med 2014;371:203–212.
EFSA Scientific Committee on Food (2002). Opinion on the tolerable upper intake levels of nicotinic acid and nicotinamide (niacin).
NHS. Vitamins and minerals: niacin (vitamin B3). nhs.uk/conditions/vitamins-and-minerals/vitamin-b

Ingredients & nutrition

Per daily dose (1 tablet): niacin (as nicotinic acid, sustained release) 500 mg (3,125% NRV). 120 tablets, 120 daily doses.

Other ingredients: vegetable waxes (rice bran and/or carnauba wax), stearic acid, magnesium stearate (vegetable source), silica.

Always check the pack you receive, as manufacturers sometimes update recipes.

How to use

Label directions: 1 tablet a day with food. Do not exceed the stated daily dose. Only use under medical supervision, as this dose is far above UK guidance. Flushing, warmth and itching are common; avoid alcohol and hot drinks around the time you take it. Not for use in pregnancy or with liver problems.

Price per dose & how it compares

Product	Size	Price	Per daily dose
This product	120 tablets	£20.60	£0.17
Life Extension Vitamin B3 Niacin		from £8.25	£0.08
Life Extension No Flush Niacin		from £18.59	£0.19
Osavi Niacinamide		from £6.95	£0.12

Cost per daily dose lets you compare packs of different sizes fairly.Worked out from our current prices.

Food supplements should not replace a varied, balanced diet and healthy lifestyle. General information, not medical advice. Speak to your GP or pharmacist first if you are pregnant or breastfeeding, have a medical condition or take medication.