Cytoplan Joint Health - CytoProtect

Collagen protein· evidence: Limited

Collagen protein is made from animal skin, bones or fish scales. It counts as protein on a label, but it is an incomplete protein: it is missing tryptophan and is low in leucine. That makes it a poor choice if your main aim is building muscle.

For muscle, a complete protein such as whey, milk, egg, soy or a plant blend is a better use of your money.

Typical dose: Varies by product

Safety: Made from animal or fish sources. Check the label for fish or other allergens.

Research we looked at:
Morton RW et al. (2018). A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med 52:376–384.
Jäger R et al. (2017). International Society of Sports Nutrition position stand: protein and exercise. J Int Soc Sports Nutr 14:20.
GB Nutrition and Health Claims Register: authorised claims for protein.

Chondroitin· evidence: Limited

Chondroitin sulphate is another natural part of cartilage. In supplements it usually comes from cow, pig, chicken or shark cartilage, and a few vegan versions are made by fermentation. It is often paired with glucosamine.

The research is mixed. Large independent trials found little or no benefit over a dummy pill for most people, while some smaller and maker-funded trials looked more positive, and the quality of chondroitin in supplements varies. EFSA rejected a claim that it helps keep joints healthy, and NICE does not recommend it on the NHS.

There is no authorised health claim for chondroitin, so we make no claims about what it does. Studies have mostly used 800–1,200 mg a day; many combination products contain far less.

Typical dose: Studies mostly used 800–1,200 mg a day

Safety: Usually made from animal cartilage, so not suitable for vegetarians unless stated. May add to the effect of warfarin and other blood thinners: speak to your GP or pharmacist first if you take them. Not recommended in pregnancy or breastfeeding without advice.

Research we looked at:
Clegg DO et al. (2006). Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354:795–808.
Singh JA et al. (2015). Chondroitin for osteoarthritis. Cochrane Database Syst Rev (1):CD005614.
Wandel S et al. (2010). Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ 341:c4675.
NICE (2022). Osteoarthritis in over 16s: diagnosis and management. NICE guideline NG226.

Cost per daily dose lets you compare packs of different sizes fairly.Worked out from our current prices.