Applied Nutrition NAD+ Resveratrol

Resveratrol· evidence: Insufficient

Resveratrol is a plant compound found in grape skins, red wine, peanuts and Japanese knotweed, which is the usual source for supplements. Much of the interest comes from laboratory and animal studies on ageing.

Human trials are small and short, and their results have been inconsistent; it is also poorly absorbed. There are no authorised health claims for resveratrol, so we make no claims about what it does. Products that pair it with 'NAD+' are based on early-stage research, and swallowed NAD+ itself is largely broken down before it is absorbed.

Typical dose: Supplements typically give 100 to 500 mg a day. EFSA considers up to 150 mg a day of trans-resveratrol safe for adults as a novel food.

Safety: Higher doses can upset the stomach. Resveratrol may add to the effect of blood thinners and affect how some medicines are broken down. Avoid in pregnancy and breastfeeding, and speak to your GP first if you take regular medication or have a hormone-sensitive condition.

Research we looked at:
EFSA NDA Panel (2016). Safety of synthetic trans-resveratrol as a novel food pursuant to Regulation (EC) No 258/97. EFSA Journal 14(1):4368.
Tomé-Carneiro J et al. (2013). Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Current Pharmaceutical Design 19(34):6064-6093.